Skip to main content
. 2019 Apr 24;10:878. doi: 10.3389/fimmu.2019.00878

Figure 4.

Figure 4

Frequency of SHM in naïve, unswitched (USm) and switched (Sm) memory B cells in healthy donors (blue) and CVID patients (red). By definition, naïve B cell do not undergo SHM, the frequency of SHM is severely reduced in USm and Sm in CVID patients. The P-value is shown for comparisons between HD and CVID patients with a statistically significant difference by Mann-Whitney test (***p < 0.001). Box and whiskers with minimum to maximum.