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Schematic of neural pathways. Sympathetic and para-sympathetic fibers innervate the lacrimal gland, signaling to receptors on the basal membrane of the acinar cells. Scopolamine blocks the efferent parasympathetic fibers. Prazosin inhibits sympathetic efferent fibers. Hexamethonium blocks synapses in ganglia and prevents afferent nerve inputs from reaching the acinar cells and generating tears.
