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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Neural Eng. 2015 Dec 10;13(1):016006. doi: 10.1088/1741-2560/13/1/016006

Figure 4.

Figure 4.

Effects of neural blockers on stimulated tear volume. (a) Tear volume above baseline for gland stimulation (6 mA, 500 μs pulses repeated at 30 Hz for 5 min) with scopolamine (1.5 mg kg−1, n=5), prazosin (2.0 mg kg−1, n=5), hexamethonium(10 mg kg−1, n=7) and no blockers (control, n=10). Scopola-mine blocked the efferent parasympathetic pathway. Hexamethonium did not affect tearing; suggesting afferent nerves were not involved. (b) Tear increase over baseline for afferent nerve stimulation with hexamethonium (10 mg kg−1) and without (control). Hexamethonium blocked tearing from corneal (6 mA, 500 μs pulses at 30 Hz for 10 s, n=6) and ethmoid nerve (2–3 mA, 200 μs pulses at 30 Hz Hz for 5 min, n=5) stimulations: *p ≤ 0.01, compared to control.