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. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Carbohydr Res. 2019 Mar 19;476:65–70. doi: 10.1016/j.carres.2019.03.001

Table 1.

Inhibition and selectivity ratio for CA II and CA IX with 1a-c, and AZM

	IC₅₀ (nM)		selectivity ratio^a
Compound	CA II	CA IX	CA II:CA IX
1a	>2000	197	>10
1b	>2000	206	>10
1c	>2000	93	>22
AZM^b	12	25	0.5

^a

Selectivity is determined by the ratio of IC₅₀s for the cytosolic CA II relative to the targeted CA IX isoform.

^b

AZM = acetazolamide