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. 2017 Feb 15;23(3):257–265. doi: 10.1111/cns.12672

Figure 6.

Figure 6

Lenti‐siHM13 inhibited tumorigenesis and invasiveness in a U87EGFRvIII orthotopic model in vivo. (A) Overall animal survival was assessed by Kaplan–Meier survival curves in the two groups. (B) Detection of TGF‐β1 and TGF‐α by ELISA in blood derived from mice bearing tumors. (C) The tissue slices from representative tumors in each group were stained with hematoxylin–eosin–saffron; the small black arrow indicates tumor metastasis. (D) TGF‐β1 and p‐smad2 expression were confirmed using confocal microscopy (1000×). The scale bar corresponds to 20 μm. Error bars represent the means ± SD obtained from three independent experiments.