Figure 3.

Effects of PI3K knockdown in the RVLM on changes in cardiovascular function and proinflammatory cytokines induced by intracisternal infusion of Ang II (1 wk) in WKY rats. A: time courses of systolic blood pressure (SBP) and HR in the WKY rats treated with intracisternal infusion of Ang II in response to pretreatment with lenti‐GFP or lenti‐PI3K shRNA injected into the RVLM (arrows). Values are expressed as mean±SEM, n=5/group, *P<.05 vs 0 d, #P<.05 vs lenti‐GFP. B, the Ang II‐induced changes in IL‐1β, IL‐6, and TNF‐α in the RVLM in response to pretreatment with lenti‐PI3K shRNA injections. Values are expressed as mean±SEM, n=5/group. *P<.05 vs aCSF, ^# P<.05 vs lenti‐GFP