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. 2017 Feb 6;23(4):301–309. doi: 10.1111/cns.12675

Figure 4.

Figure 4

Ciproxifan rescues hippocampal synaptic plasticity after isoflurane. (A, C), fEPSP traces at the basal‐dendritic electrode of representative rats at 0 (baseline), 5, 30, 60, 120, and 180 min after tetanus, with tetanus given 30 min after i.p administration of either saline or ciproxifan in vehicle gas (A) and isoflurane (C)‐exposed rats. (B) Normalized fEPSP slopes with LTP induced after vehicle gas exposure and administration of either saline or ciproxifan 30 min before tetanus. (D) Normalized fEPSP slopes with LTP induced after isoflurane exposure and administration of either saline or ciproxifan 30 min before tetanus. Data are expressed as mean ± SEM. A two‐way repeated‐measures ANOVA revealed a significant effect of isoflurane versus vehicle gas for LTP induction, and a significant effect of ciproxifan versus saline for LTP induction in isoflurane‐exposed rats, n = 6 per group.