Table 1.

Cox proportional hazard regression analyses of PXN expression and clinicopathological factors affecting overall survival of GBM patients

Variable	Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	P Value
Gender (male vs. female)	1.227	0.795–1.893	0.355
PXN (high vs. low)	1.677	1.099–2.558	0.017	1.939	1.112–3.38	0.020
IDH1 (mutation vs. wild type)	0.638	0.380–1.072	0.089
MGMT (methylation vs. no)	0.564	0.364–0.872	0.010	0.628	0.379–1.038	0.070
Age (≥60 vs. <60)	1.723	1.041–2.850	0.034	1.278	0.693–2.356	0.432
TMZ (received vs. no)	0.336	0.214–0.528	<0.01	0.493	0.287–0.847	0.010
Radiotherapy (received vs. no)	0.412	0.259–0.654	<0.01	0.368	0.218–0.621	<0.01
Increasing KPS	0.967	0.952–0.982	<0.01	0.969	0.947–0.991	0.006
Extent of resection (subtotal vs. total)	1.645	1.090–2.482	0.018	1.562	0.922–2.646	0.097

HR, hazard ratio.