Figure 2.

Post hoc tests and correlative analyses performed in overlapping regions. (A) In the left middle frontal gyrus, CLU‐CC carriers in both the aMCI group and the RGD group displayed longitudinally increased FC. (B) In the left medial orbital frontal gyrus, CLU‐CT/TT carriers in both the aMCI group and the RGD group displayed longitudinal decrease trends of FC. (C) For control CLU‐CT/TT subgroup, greater increase of FC with the left middle frontal gyrus was associated with less decline in episodic memory scores (r=.420, P=.046, two‐tailed). (D) For the aMCI CLU‐CT/TT subgroup, greater decrease of FC with the left medial orbital frontal gyrus was associated with less decline in episodic memory scores (r=−.650, P=.030, two‐tailed). * P<.05. DMN, default mode network; FC, functional connectivity