Table 2.

Main clinical features of the heterozygous HTRA1 mutation carriers

Patients	Mutation	Sex	Age	Onset (y)	Vascular risk factors	Symptoms at onset	TIA/stroke	Cognitive decline	Gait disturbances	Affected relatives
F1 (II,3)	p.Gly295Arg	M	73	65	‐	Cognitive decline	‐	+	+	5
F1 (II,5)	p.Gly295Arg	M	71	67	Hypertension	Cognitive decline	+	+	‐	5
F1 (II,9)	p.Gly295Arg	M	63	‐	‐	‐	‐	‐	‐	5
F1 (III,3)	p.Gly295Arg	M	49	‐	‐	‐	‐	‐	‐	5
F2 (II,1)	p.Gly206Glu	M	65	55	Hypertension	Gait disturbances	‐	+	+	1
F3 (IV,1)	p.Ser136Gly	F	77	63	‐	Gait disturbances	+	+	+	2
F4 (II,1)	p.Val175Met	M	Died (77)	59	Hypertension Dyslipidemia	Gait disturbances	+	+	+	1
F4 (III,2)	p.Val175Met	F	46	‐	‐	‐	‐	‐	‐	1
F5 (II,1)	p.Gln151Lys	M	61	59	‐	Gait disturbances	‐	+	+	2