Figure 4.

NDRG2 facilitates the hyperphosphorylation of tau. (A) Image of PHF in SK‐N‐SH and SK‐N‐SH APPwt cells. (B) Representative Western blots and quantification of phosphorylated tau at Ser199, Thr205, and Ser396 after SK‐N‐SH APPwt cells were transfected with siControl or siNDRG2. (C) Representative Western blots and quantification of phosphorylated tau at Ser199, Thr205, and Ser396 after SK‐N‐SH cells were transfected with Ad‐NDRG2 or Ad‐lacZ. Quantified results were normalized to β‐actin expression. For all the results above, a representative experiment of three performed is shown. Values were expressed as percentages compared to the control group (set to 100%) and represented as group mean±SEM. n=4~5 per group. *P<0.05, **P<0.01 vs control group