Table 2.
The pathways of DEGs involved using GO analysis
| No. | Pathway | −LgP | No. | Pathway | −LgP |
|---|---|---|---|---|---|
| 1 | G protein‐coupled receptor signaling pathway | 14.86 | 43 | positive regulation of G protein‐coupled receptor protein signaling pathway | 3.51 |
| 2 | Multicellular organismal development | 8.66 | 44 | Negative regulation of very‐low‐density lipoprotein particle clearance | 3.49 |
| 3 | Positive regulation of transcription from RNA polymerase II promoter | 8.02 | 45 | Negative regulation of lipid metabolic process | 3.49 |
| 4 | Neuropeptide signaling pathway | 7.50 | 46 | Regulation of dopamine uptake involved in synaptic transmission | 3.49 |
| 5 | Cell adhesion | 7.24 | 47 | Visual perception | 3.47 |
| 6 | Cell differentiation | 6.86 | 48 | Transmembrane transport | 3.43 |
| 7 | Synaptic transmission | 6.80 | 49 | Positive regulation of ERK1 and ERK2 cascade | 3.39 |
| 8 | Sensory perception of taste | 6.60 | 50 | Negative regulation of neuron differentiation | 3.36 |
| 9 | Brain development | 5.84 | 51 | Negative regulation of apoptotic process | 3.33 |
| 10 | G protein‐coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 5.81 | 52 | Regulation of dopamine secretion | 3.30 |
| 11 | Cell‐cell signaling | 5.60 | 53 | Dopamine metabolic process | 3.30 |
| 12 | Keratinization | 5.40 | 54 | Glucose homeostasis | 3.30 |
| 13 | Proteolysis | 5.40 | 55 | Epidermis development | 3.25 |
| 14 | Transcription, DNA‐dependent | 5.37 | 56 | Negative regulation of phosphatase activity | 3.23 |
| 15 | Immune response | 5.36 | 57 | Response to amphetamine | 3.18 |
| 16 | Pattern specification process | 5.17 | 58 | Regulation of glucose metabolic process | 3.11 |
| 17 | Inflammatory response | 5.00 | 59 | Neuron fate specification | 3.11 |
| 18 | Positive regulation of cell proliferation | 4.77 | 60 | Negative regulation of protein secretion | 3.11 |
| 19 | Adenylate cyclase‐activating G protein‐coupled receptor signaling pathway | 4.75 | 61 | Negative regulation of inflammatory response | 3.11 |
| 20 | Regulation of immune response | 4.63 | 62 | Adenylate cyclase‐inhibiting dopamine receptor signaling pathway | 3.11 |
| 21 | Positive regulation of actin filament polymerization | 4.59 | 63 | Glycerol transport | 3.11 |
| 22 | Negative regulation of retinoic acid receptor signaling pathway | 4.59 | 64 | Negative regulation of interleukin‐5 production | 3.11 |
| 23 | Behavioral response to cocaine | 4.42 | 65 | Drinking behavior | 3.11 |
| 24 | T cell costimulation | 4.39 | 66 | Type B pancreatic cell proliferation | 3.11 |
| 25 | Signal transduction | 4.24 | 67 | Lateral mesoderm development | 3.11 |
| 26 | Synaptic transmission, dopaminergic | 4.20 | 68 | Feeding behavior | 3.09 |
| 27 | Cell surface receptor signaling pathway | 4.18 | 69 | Defense response | 3.07 |
| 28 | Response to histamine | 4.09 | 70 | Humoral immune response | 3.03 |
| 29 | Negative regulation of dopamine receptor signaling pathway | 4.09 | 71 | Positive regulation of smooth muscle cell proliferation | 3.03 |
| 30 | Biological process | 4.01 | 72 | Eating behavior | 3.01 |
| 31 | Potassium ion transport | 4.00 | 73 | Chondrocyte differentiation | 2.93 |
| 32 | Positive regulation of sequence‐specific DNA binding transcription factor activity | 3.98 | 74 | Negative regulation of adenylate cyclase activity | 2.90 |
| 33 | Nervous system development | 3.95 | 75 | Adult walking behavior | 2.85 |
| 34 | Positive regulation of canonical Wnt receptor signaling pathway | 3.95 | 76 | Forebrain development | 2.84 |
| 35 | Negative regulation of cell differentiation | 3.94 | 77 | Positive regulation of protein processing | 2.82 |
| 36 | Regulation of sequence‐specific DNA binding transcription factor activity | 3.89 | 78 | Chylomicron remnant clearance | 2.82 |
| 37 | Interferon‐gamma‐mediated signaling pathway | 3.83 | 79 | Negative regulation of receptor‐mediated endocytosis | 2.82 |
| 38 | Keratinocyte differentiation | 3.75 | 80 | Negative regulation of neuron death | 2.82 |
| 39 | Positive regulation of protein kinase B signaling cascade | 3.66 | 81 | Positive regulation of cell‐cell adhesion mediated by cadherin | 2.82 |
| 40 | Positive regulation of mesenchymal cell proliferation | 3.65 | 82 | Positive regulation of filopodium assembly | 2.80 |
| 41 | Learning or memory | 3.56 | 83 | Ion transmembrane transport | 2.79 |
| 42 | Oxygen transport | 3.51 |