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. 2016 Oct 19;23(2):119–126. doi: 10.1111/cns.12649

Figure 3.

Figure 3

Methamphetamine (METH) impairs ex vivo glucose uptake in depolarized frontocortical slices. (A) Whereas resting glucose uptake by frontocortical slices was not significantly different between groups (n = 8; P > 0.05), glucose uptake in response to lasting depolarization was lower in the METH group; (B) The density of the 45 kDa but not that of the 55 kDa GluT1 isoform was decreased in the frontal cortex of the METH group (n = 8). Inset B’ shows representative Western blot of the 45 and 55 kDa glucose transporter (GluT1) isoforms in frontocortical extracts from SAL and METH groups; (C) The density of GluT3 (45 kDa) in the frontal cortex was not significantly different between groups (n = 7, P > 0.05). Inset C’ shows representative Western blots of GluT3 (45 kDa) in frontocortical extracts from SAL and METH groups. **P < 0.01 versus saline group using an unpaired Student's t‐test between the indicated experimental groups.