Figure 3.

The effects of aromatase inhibitors on colorectal hyperalgesia and aromatase expression in the RVM. A, Protocol of the experiment. B, Bar graph comparing the abdominal withdrawal responses to colorectal distension (averaged AUC of pressure‐AWR score curves) among 5 groups of rats: saline‐treated rats (n = 6), CPM‐treated rats (n = 6), CPM + vehicle (CPM‐treated with intracisternal application of vehicle, n = 6), CPM + FAD (CPM‐treated with intracisternal application of fadrozole, n = 6) and CPM + LET (CPM‐treated with intracisternal application of letrozole, n = 7). ***P < .001, One‐Way ANOVA followed by Tukey post hoc test. C, D, Comparison of the expression level of aromatase (MW: 58 kDa) in the RVM of different groups of rats. *P < .05, ***P < .001, n = 6 for each group, One‐Way ANOVA followed by Tukey post hoc test