α‐M did not affect protein expression of secretases and amyloid precursor protein(APP) metabolism in primary cortical neurons. APP (mAPP, imAPP), IDE, BACE1 and PS1 protein expressions were immunoblotted (A) and quantified (B for mAPP, imAPP and mAPP:imAPP ratio, and C for IDE, BACE1, PS1) from cultured cortical neurons incubated with various concentration of α‐M for 24 h. Data represent mean ± SEM of at least three independent experiments