Figure 4.

α‐M inhibited β‐secretase and likely γ‐secretase activities. (A) The activities of α‐, β‐ and γ‐secretases were measured from cortical neurons incubated with various concentrations of α‐M for 24 h. *P<.05, **P<.01, compared with 0 nmol·L⁻¹ of α‐M. (B) α‐M inhibited β‐secretase (BACE1) activity by in vitro FRET assay. Data represent mean ± SEM of at least three independent experiments performed in triplicate