Figure 3.

Effect of acute administration of LP‐44 alone or after administration of Asenapine on the neuronal firing activity of dorsal raphe (DR) 5‐HT cells. (A) Integrated firing rate histogram of a presumed DR 5‐HT cell showing its response to successive doses of LP‐44 (1‐4 mg/kg, i.v.). (B) Dose‐response curve of the inhibitory effect of LP‐44 made with cumulative doses (1‐4 mg/kg, i.v.) alone or with a prior administration of SB 269970 (1 mg/kg, i.v.). (C) Integrated firing rate histogram of a presumed DR 5‐HT neuron showing its response to cumulative doses of LP‐44 (1‐5 mg/kg i.v.) after a prior administration of Asenapine (1 mg/kg i.v.). (D) Dose‐response curve of the inhibitory effect of LP‐44 made with cumulative doses (1‐4 mg/kg, i.v.) alone or after administration of Asenapine (1 mg/kg, i.v.). Each symbol represents the mean compare to control of DR 5‐HT cell firing (in percentage ± S.E.M.). *P<.05, and **P<.01, as compared to control using two‐way repeated‐measures ANOVA