Figure 4.

Effect of chronic treatment with Asenapine on the firing activity of DR 5‐HT neurons. (A) Mean ± SEM of the spontaneous firing rate of DR 5‐HT neurons in control and in rats treated with Asenapine (0.3 mg/kg/d, s.c.) for 3, 14 or 21 d. The numbers indicate the total number of recorded neurons in each group of treated rats. *P<.05 and **P<.01, as compared to control using one‐way ANOVA followed by Fisher PLSD post hoc test. Dose‐response curve of the suppressant effect of cumulative doses of (B) LP‐44 (1‐4 mg/kg, i.v.), (C) flesinoxan (100‐400 μg/kg, i.v.), and (D) dexmedetomidine (10‐20 μg/kg, i.v.) in controls and in rats treated for 14 d with Asenapine (0.3 mg/kg/d, s.c.). Each symbol represents the mean compare to control of DR 5‐HT cell firing (in percentage ± SEM). *P<.05, as compared to control using two‐way repeated‐measures ANOVA