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. 2016 Jun 19;22(10):807–816. doi: 10.1111/cns.12572

Figure 2.

Figure 2

Vaccination downmodulated peripheral cytokine production in infected EAE mice. C57BL/6 mice were vaccinated with MOG+VitD, infected with C. albicans, and then submitted to EAE induction. IL‐6 (A), IL‐17 (B), TNF‐α (C), IFN‐γ (D), IL‐2 (E), IL‐10 (F), and TGF‐β (G) levels were measured in spleen cell cultures (5 × 106 cells/mL) stimulated with MOG (20 μg/mL) at early clinical (10th day) and clinical (17th day) EAE phases. The results are expressed as mean ± SD (6–14 cultures/group), and results from two independent experiments were combined. *P < 0.05, **P < 0.01, and ***P < 0.001 indicate difference among groups. # indicates difference between time points of analysis.