Table 1.
List of the antiepileptic drugs (AED) used in this study with their primary known targets (adapted from 20) chemical name and dosage form
| AEDs | Primary target | Chemical name | Dosage form |
|---|---|---|---|
| Valproic acid | Voltage‐gated Na+ channel/T‐type Ca2+ channel | Sodium 2‐propylpentanoate | Valproic acid sodium salt |
| Lamotrigine | Voltage‐gated Na+ channel | 6‐(2,3‐dichlorophenyl)‐1,2,4‐triazine‐3,5‐diamine | Powder |
| Carbamazepine | Voltage‐gated Na+ channel | 5H‐dibenzo[b,f]azepine‐5‐carboxamide | Powder |
| Levetiracetam | SV2A | (S)‐2‐(2‐Oxopyrrolidin‐1‐yl)butanamide | Liquid solution (100 mg/mL) |
| Pregabalin | α 2 δ subunit of the voltage‐dependent Ca2+ channel | (S)‐(+)‐4‐Amino‐3‐(2‐methylpropyl)butanoic acid | Powder |
| Tiagabine | GABA reuptake | (R)‐1‐[4,4‐bis(3‐methylthiophen‐2‐yl)but‐3‐enyl] piperidine‐3‐carboxylic acid | Powder |
| Vigabatrin | GABA transaminase | (RS)‐4‐aminohex‐5‐enoic acid | Powder |
| Diazepam | GABAA | 7‐chloro‐1‐methyl‐5‐phenyl‐3H‐1,4‐benzodiazepin‐2‐one | Liquid solution (5 mg/mL) |
| Phenobarbital | GABAA | 5‐Ethyl‐5‐phenyl‐1,3‐diazinane‐2,4,6‐trione | Liquid solution (20 mg/mL) |