Table 3.

Quantitative EEG modifications of power spectra for hippocampal paroxysmal discharges (HPDs) and interictal periods induced by AEDs. For each AED, the dose chosen is the lowest inducing a significant antiepileptic effect (see Table 2). Modifications of power were calculated as percent change between the posttreatment and the pretreatment periods for each animal

AED	Dose (mg/kg)	n	Postdrug HPD power changes						Postdrug interictal power changes
			δ	θ	α	β	γ	Minutes posttreatment	δ	θ	α	β	γ	Minutes posttreatment
Valproate	300	6	ns	ns	ns	ns	ns	10–70	ns	↓	ns	ns	ns	10–30
Pregabalin	50	8	ns	ns	ns	↓	↓	10–70	ns	ns	ns	ns	ns	10–30
Lamotrigine	90	7	ns	ns	ns	↓	↓	60–120	ns	↓	↓	↓	↓	60–120
Carbamazepine	75	8	↑	↑	↑	↑	ns	10–70	ns	ns	ns	↑	↑	10–30
Tiagabine	0.3	8	ns	ns	ns	ns	↓	10–70	ns	ns	ns	ns	ns	10–30
Vigabatrin	50	7	ns	ns	ns	ns	ns	180–240	ns	ns	ns	ns	ns	180–240
Diazepam	1	5	↓	ns	ns	ns	ns	10–70	↑	↑	ns	↑	↑	10–30
Phenobarbital	20	6	ns	ns	ns	↓	ns	10–70	ns	ns	ns	ns	ns	10–30
Levetiracetam	600	6	ns	ns	ns	ns	ns	10–70	ns	ns	ns	ns	ns	10–30

The EEG signals from some animals included in Table 2 were not used for quantitative EEG analyses because they displayed too many movement artifacts. Statistical significance (threshold P = 0.05) of power change per frequency band was determined by comparing the actual mean of the power change to a hypothetical value (0) using a one‐sample t‐test (for normally distributed data) or a signed‐rank Wilcoxon test (for nonnormally distributed data). ns: nonsignificant; ↑: significant power increase; ↓: significant power decrease.