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. 2016 Jul 20;22(12):979–987. doi: 10.1111/cns.12594

Figure 4.

Figure 4

L‐NBP treatment improved spine density in the hippocampus of APP/PS1 mice. (A) Golgi staining of the hippocampal area (top), L‐NBP‐mediated preservation of the number of spines per given dendritic length in the hippocampus CA1 (middle) and DG (bottom of APP/PS1 mice. Scale bar=5 μm. (B–C) Quantitative analysis of spine density in CA1 (B) and DG (C). The spine number was decreased in the APP/PS1 mice treated with vehicle. L‐NBP rescued the impaired spine density both in CA1 and DG area. Data were expressed as the mean ± SEM. n = 7–12 dendrites per animal, 3–5 animals per group. ### P < 0.001 versus control‐treated wild‐type group. ***P < 0.001 versus control‐treated APP/PS1 group.