Figure 6.

The effects of NS383 on motor function and coordination in naive rats. Normal, uninjured rats were administered either NS383 (120–480 mg/kg, i.p.), amiloride (50–200 mg/kg, i.p.), morphine (6–24 mg/kg, s.c.), acetaminophen (200–800 mg/kg, i.p.), or vehicle immediately after a baseline response had been obtained and the effects on motor performance (represented as % Baseline) determined. Data are presented as mean ± SE. All groups n = 8 rats except for NS383 120 mg/kg n = 7 rats, NS383 240 mg/kg n = 7 rats. Note that the Vehicle group indicated is comprised of rats from each individual experiment and is shown for reference purposes only. *P < 0.05, ***P < 0.001 versus corresponding vehicle (one‐way ANOVA followed by Dunn's test).