Figure 4.

The effect of ST10 on free radical scavenging. (A) ESR spectra of HO radical detected in the reaction mixture containing 500 μM H₂O₂, 30 mM PBN, and 0.2 mM FeSO ₄ (A) vehicle‐1% (v/v) DMSO, (b) 200 μM tacrine, (c) ST09, and (d) ST10. (e) Peak intensity of the HO ESR signal detected in the reaction mixture in the presence of vehicle, tacrine, ST09, and ST10. Data are presented as mean percentage of vehicle ± SEM. **P < 0.01 vs. vehicle. (B–E) Effects of ST09 on protein‐bound SH group level (B), MDA level (C), and SOD activity (D–E). Data are presented as mean ± SEM. n = 5–6. *P < 0.05, **P < 0.01 vs sham; ^# P < 0.05, ^## P < 0.01 vs. 2‐VO by one‐way ANOVA followed by LSD multiple comparisons post hoc tests.