Figure 2.

The effect of exogenous ORM on the performance of stroke mice in Morris water maze testing. (A) Serum ORM level in mice 24 h after sham operation or MCAO. N = 6 per group. (B–D) Mice underwent sham operation, MCAO with or without ORM treatment (50 mg/kg via tail vein 30 min ahead of each Morris water maze [MWM] testing), and MWM testing was started on the 7th day post‐MCAO. (B) Average latency to platform of 4 trials per day for the consecutive 4 days. (C) Mean number of platform crossing on the 5th day. (D) Representative swim path of mice after platform is removed on the 5th day. Green circle indicates the previous location of platform. N = 9 per group for B–D. Data are presented as mean ± SEM and analyzed by Student's t‐test for A and one‐way analysis of variance for B and C. P < 0.05 was considered statistically significant.