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Lesions in the brain and spinal cord of a patient using fingolimod. The frontal lesion seems to have concentric layers in the white matter substance (A) and is enhanced by gadolinium, forming a ring (B, C). This frontal lesion does not invade the cortical grey matter layer (A). Spinal cord lesions affect both cervical and thoracic segments (E, F, G). Two months after fingolimod withdrawal, the lesions were markedly reduced (H, I).
