Table 2.

A 2‐Year follow‐up on NMOSD patients after MSC infusion

	Before MSC	1 year after infusion	2 years after infusion	P1	P2	P3
ARR, mean (SD; range)	1.1 (0.9; 0.3–4.0)	0.3 (0.6; 0–2.0)	0.1 (0.3; 0–1.0)	0.002	<0.0001	0.894
Relapse free, n (%)	5* (33%)	12 (80%)	13 (87%)	0.025	0.008	1.000
EDSS, mean (SD; range)	4.9 (2.1; 2.5–8.5)	4.3 (2.2, 1.0–8.5)	4.0 (2.3, 1.0–8.5)	0.021	<0.0001	0.861
EDSS score change, n (%)				0.001	0.002	0.713
Decreased EDSS score	2* (13%)	7 (47%)	6 (40%)
Stable EDSS score	4* (27%)	8 (53%)	9 (60%)
Increased EDSS score	9* (60%)	0	0

Wilcoxon signed rank test (ARR, ESS); chi‐square test (Relapse free, EDSS score change);

*the last year before autologous mesenchymal stem cell infusion; P1 = (before MSC) versus (1 year after infusion); P2 = (before MSC) versus (2 years after infusion);

P3 = (1 year after infusion) versus (2 years after infusion).