Table 1.
Overview of the proneurogenic and neuroprotective effects of the P7C3 family
| Year | Studied chemical | Experimental model | Proneurogenic and neuroprotective effect |
|---|---|---|---|
| 2010 96 | P7C3 and its analogs |
NPAS3−/− mouse model of neurological malfunctions U2OS cell model of calcium‐induced mitochondrial dissolution Aged rat |
Enhance neuron formation in the SGZ of the DG Rescue NPAS3−/−‐induced loss of hippocampal neurogenesis Ameliorate cognitive decline in aged rat |
| 2012 102 |
P7C3 P7C3‐A20 |
MPTP‐mediated mouse model of PD MPP+‐mediated worm model of PD |
Protect mature neurons in the mouse brain region outside of hippocampus Protect substantia nigra dopaminergic neurons from cell death |
| 2012 109 |
P7C3 P7C3‐A20 |
G93A‐SOD1 mutant mouse model of ALS | Protect ventral horn spinal cord motor neurons from cell death |
| 2013 99 | Compound 9 | Cultured rat cortical NSCs | Induce neurogenesis to enhance neuronal differentiation and inhibit astrocytogenesis |
| 2014 108 |
P7C3 P7C3‐A20 |
Depression‐prone ghrelin receptor‐null mouse model |
Increase proliferating DG cell survival and mature neuron formation Augment hippocampal neurogenesis following focal ablation of hippocampal stem cells |
| 2014 104 | P7C3‐A20 | Moderate fluid percussion brain injury rat model of TBI | Increase proliferating neurons and improve cognitive function after TBI |
| 2014 97 | (‐)‐P7C3‐S243 |
Mouse model of hippocampal neurogenesis MPTP‐mediated mouse model of PD |
Protect developing neurons in hippocampal neurogenesis Protect mature neurons within the substantia nigra in PD |
| 2014 105 | (‐)‐P7C3‐S243 | Blast‐mediated rodent model of TBI | Block brain axonal degeneration and preserve learning, memory, and motor coordination |
| 2015 106 | P7C3 | Rat model of nerve crush injury | Enhance neuron survival, axonal regeneration and prevent microglia proliferation |
| 2015 107 | P7C3 | Ts65Dn mouse model of DS | Increase hippocampal neurogenesis in Ts65Dn mice |
| 2015 103 | Compound 1 | Cultured rat cortical NSCs | Enhance neurogenesis by increasing final cell division |
AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; DG, dentate gyrus; DS, Down syndrome; MPP, 1‐methyl‐4‐phenylpyridinium; MPTP, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine; NAD, nicotinamide adenine dinucleotide; NPAS3, PAS domain protein 3; NSCs, neural stem cells; PD, Parkinson's disease; SGZ, subgranular zone; TBI, traumatic brain injury.