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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Neuropharmacology. 2017 Sep 22;128:11–21. doi: 10.1016/j.neuropharm.2017.09.030

Fig. 5. Ethanol effect on LPS-induced IL-1β (A) and TNFα (B) secretion from BV2 microglial cells.

Fig. 5.

A. Activation of P2X4Rs and P2X7Rs significantly increased LPS-induced IL-1β secretion. Ethanol alone enhanced the cytokine release in a concentration dependent manner (25 and 100 mM). The effect on P2X7Rs but not P2X4Rs was further potentiated by ethanol reaching significance at 100 mM. B. Ethanol did not modulate LPS-induced TNFα secretion from BV2 cells in the absence or presence of 0.1 and 1.0 mM ATP. Data presented as mean ± SEM from 4 separate experiments. Two-way ANOVA - *P < 0.05, compared to LPS-100 mM ethanol; #P < 0.05, versus LPS+0.1 mM ATP-100 mM ethanol.