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. 2019 Mar 20;141(14):6054–6059. doi: 10.1021/jacs.9b01819

Scheme 1. Synthesis of Double Overhand Knot (Λ,Δ)-L3•[Lu]2 and Square Knot (Λ,Δ)-1.

Scheme 1

Reagents and conditions: (i) Cu(MeCN)4(CF3SO3), Tentagel-TBTA, MeCN/MeOH 1:1, RT, 16 h, 70%. (ii) Hoveyda-Grubbs second generation catalyst, MeNO2/CH2Cl2 1:1, 30%. (iii) Et4NF, MeCN, RT, 5 min, 95%.