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. 2019 Mar 16;8(5):e1577127. doi: 10.1080/2162402X.2019.1577127

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — SpCas9 stimulates immune response in C57BL/6J immunocompetent mice. (a) Growth curves depicting average tumor volumes (±SD) of mT3-2D (n = 10) and mT3-2D-ELC4 (n = 10) grown in immunocompetent WT mice. (b) Detection of anti-SpCas9 IgG1 levels in serum of immunocompetent mice.