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. 2019 Mar 30;8(6):e1586042. doi: 10.1080/2162402X.2019.1586042

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 6. — Motif analysis of TCR expanded by neoantigens. a) Sequence motifs of the CDR3 regions for the most frequent clones (HIGH) and the least frequent ones (LOW) expanded upon coculture with APC stimulated by neoantigen 9 or neoantigen 17 (b). c) DiffLogo analysis showing the differences between the HIGH and LOW motifs for TCR specific for neoantigen 9 or 17 (b). The x-axis indicates the antigen position, the y-axis indicates the difference (as JS divergence) between the two different motifs. Asterisks indicate locations that are significantly different between the HIGH and LOW motifs.