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. 2019 Mar 28;8(6):e1593811. doi: 10.1080/2162402X.2019.1593811

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Elevated expression of mediators associated with Th1, Th2 or Th17 lymphocyte subsets is associated with improved 5-year overall survival in ovarian cancer.

(a) Heatmap illustrating the association of elevated intratumoral expression of 22 individual cytokines in Th1, Th2, Th9 and Th17 categories, with 5-year overall survival of ovarian cancer patients. HR < 1, indicates better survival of patients (depicted in dark green). HR > 1 indicates disadvantage to survival of patients (red). HR of 1 indicates no prognostic value. (b) All combinations tested within Th1: n = 255, Th2: n = 98, and Th17: n = 30, are shown as pie chart and dot plot graphs. (c) Heatmap illustrating the patient survival when up to four mediators that are independently associated with better prognosis (CXCL-9, CXCL-10, CXCL-11, and IFNγ) are combined. The three combinations associated with the best prognosis are highlighted on Kaplan-Meier survival curves. (P-values: * = P < 0.05, ** = P < 0.01, *** = P < 0.001, **** = P< 0.0001).