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. 2019 Feb 19;8(5):e1574198. doi: 10.1080/2162402X.2019.1574198

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 7. — Characterization of the enzymatic and immunosuppressive function of adenosinergic ectoenzymes on MV.

The enzymatic function of CD73, CD203a/PC-1, CD38, and CD39 was evaluated on pooled MV from five NB patients (gray bars) and five controls (white bars), using as substrate adenosine 5ʹ-monophosphate (AMP, panel a), adenine diphosphate ribose (ADPR, panel b), nicotinamide adenine dinucleotide (NAD⁺, panel c) and adenosine 5ʹ-triphosphate (ATP, panel d). Results are expressed as nmol of substrate, adenosine (ADO) or the byproducts AMP, adenosine 5ʹ-monophosphate (ADP), ADPR, inosine (INO), inosine monophosphate (IMP) and nicotinamide (NIC). The immunosuppressive function of MV was evaluated by co-culturing T cells isolated from four healthy donors and stimulated with anti-CD3/CD28 beads in the presence (gray bar) or absence (white bar) of NB patients’ BM-derived MV. Histograms in panel E shows the median of four different experiments ± SEM. Histograms in panel F shows a representative experiment.