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. 2019 Feb 27;8(5):e1581546. doi: 10.1080/2162402X.2019.1581546

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Kaplan-Meier survival analysis of VISTA on the multi spot TMA (n = 165 patients). In both, surface (a) and infiltration zone (b) of the tumor, VISTA expression on tumor infiltrating T-cells (TILs) is correlated with superior overall survival compared to VISTA negative TILs. In subgroup analysis, the survival benefit of VISTA expression reveals in early invasive tumor stages (pT1/2 (c)) and is not detectable in advanced tumor stages (pT3/4 (d)). A difference in overall survival is also detectable in the validation cohort (e) which is predominantly driven by the survival difference in early tumor stages (pT1/2 (f)).