Table 1.
List of the 57 genes selected for the immune gene signature.
| ID | GeneID | GeneSymbol | GeneName |
|---|---|---|---|
| Immune cell population genes | |||
| CD2 | 914 | CD2 | CD2 molecule |
| CD3E | 916 | CD3E | CD3e molecule |
| CD4 | 920 | CD4 | CD4 molecule |
| CD8A | 925 | CD8A | CD8a molecule |
| CTLA4 | 1493 | CTLA4 | Cytotoxic T-lymphocyte associated protein 4 |
| FOXP3 | 50943 | FOXP3 | Forkhead box P3 |
| XCR1 | 2829 | XCR1 | Chemokine (C motif) receptor 1 |
| MERTK | 10461 | MERTK | MER proto-oncogene, tyrosine kinase |
| PTPRC | 5788 | PTPRC CD45 | Protein tyrosine phosphatase, receptor type C |
| MS4A1 | 931 | MS4A1 CD20 | Membrane spanning 4-domains A1 |
| NCAM1 | 4684 | NCAM1 CD56 | Neural cell adhesion molecule 1 |
| PDGFRB | 5159 | PDGFRB | Platelet derived growth factor receptor beta |
| PECAM1 | 5175 | PECAM1 | Platelet/endothelial cell adhesion molecule 1 |
| T cell activation genes | |||
| PRF1 | 5551 | PRF1 | Perforin 1 |
| GZMA | 3001 | GZMA | Granzyme A |
| GZMB | 3002 | GZMB | Granzyme B |
| Checkpoint T cell genes | |||
| CD28 | 940 | CD28 | CD28 molecule |
| ENTPD1 | 953 | ENTPD1 CD39 | Ectonucleoside triphosphate diphosphohydrolase 1 |
| NT5E | 4907 | NT5E CD73 | 5ʹ-nucleotidase ecto |
| CD96 | 10225 | CD96 | CD96 molecule, TIGIT family |
| TIGIT | 201633 | TIGIT | T-cell immunoreceptor with Ig and ITIM domains |
| CD226 | 10666 | CD226 | CD226 molecule, TIGIT family |
| TNFRSF14 | 8764 | TNFRSF14 | Tumor necrosis factor receptor superfamily member 14 |
| TNFRSF18 | 8784 | GITR | Tumor necrosis factor receptor superfamily member 18 |
| TNFRSF4 | 7293 | OX-40, CD134 | Tumor necrosis factor receptor superfamily member 4 |
| TNFRSF7 | 939 | CD27 | CD27 molecule |
| TNFRSF9 | 3604 | CD137, 4-1BB | Tumor necrosis factor receptor superfamily member 9 |
| HAVCR2 | 84868 | HAVCR2, Tim-3 | Hepatitis A virus cellular receptor 2 |
| ICOS | 29851 | ICOS | Inducible T-cell co-stimulator |
| LAG3 | 3902 | LAG3 | Lymphocyte activating 3 |
| PDCD1 | 5133 | PDCD1 | Programmed cell death 1 |
| Checkpoint tumor cell genes | |||
| IDO1 | 3620 | IDO1 | Indoleamine 2,3-dioxygenase 1 |
| CD80 | 941 | CD80, B7-1 | CD80 molecule |
| CD86 | 942 | CD86, B7-2 | CD86 molecule |
| CD276 | 80381 | CD276, B7H3 | CD276 molecule |
| LGALS9 | 3965 | LGALS9 | Lectin, galactoside-binding, soluble, 9 |
| CD274 | 29126 | CD274, PDL1 | CD274 molecule |
| PDCD1LG2 | 80380 | PDCD1LG2 | Programmed cell death 1 ligand 2 |
| ICOSLG | 23308 | ICOSLG | Inducible T-cell co-stimulator ligand |
| PVR | 5817 | PVR, CD155 (Tigit ligand) | Poliovirus receptor |
| PVRIG | 79037 | PVRIG, CD112R | Poliovirus receptor related immunoglobulin domain containing |
| TNFSF4 | 7292 | OX40L | Tumor necrosis factor superfamily member 4 |
| Inferferon signature genes | |||
| CXCL10 | 3627 | CXCL10 | C-X-C motif chemokine ligand 10 |
| IFI27 | 3429 | IFI27 | Interferon, alpha-inducible protein 27 |
| IFI44L | 10964 | IFI44L | Interferon induced protein 44 like |
| IFI6 | 2537 | IFI6 | Interferon, alpha-inducible protein 6 |
| IFIT1 | 3434 | IFIT1 | Interferon induced protein with tetratricopeptide repeats 1 |
| IRF8 | 3394 | IRF8 | Interferon regulatory factor 8 |
| MX1 | 4599 | MX1 | MX dynamin like GTPase 1 |
| OAS1 | 4938 | OAS1 | 2ʹ-5ʹ-oligoadenylate synthetase 1 |
| RSAD2 | 91543 | RSAD2 | Radical S-adenosyl methionine domain containing 2 |
| G1P2 | 9636 | ISG15 | ISG15 ubiquitin-like modifier |
| Major histocompatibility complex genes | |||
| HLA-A | 3105 | HLA-A | Major histocompatibility complex, class I, A |
| HLA-B U3/L3 | 3106 | HLA-B | Major histocompatibility complex, class I, B |
| HLA-C U2/L2 | 3107 | HLA-C | Major histocompatibility complex, class I, C |
| HLA-DRA | 3122 | HLA-DRA | Major histocompatibility complex, class II, DR alpha |
| HLA-DRB | 3123 | HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 |