Figure 1.

Survival motor neuron (SMN)‐Gemins complex members: united in diversity. Interactions between SMN‐Gemins complex members verified in one and more than one experimental system are depicted in solid and dashed arrows, respectively. Circular arrows indicate self‐association. Protein domains in the Simple Modular Architecture Research Tool (SMART) database are also indicated for each member. Only the coiled coil domain is shared by more than one complex member. The fly version of the SMN‐Gemins complex is minimalistic and composed of only SMN, Gemin2, Gemin3 and Gemin5. Addition of other components with evolution increased the complexity of the SMN‐Gemins complex to the present nine‐membered version present in vertebrates including humans (adapted from 12).