Table 2.

Effect of DSP‐4 in 6‐OHDA‐lesioned rats on tissue concentrations of DA, 5‐HT and NE in the striatum and the cortex

	Vehicle group (n = 6)		DSP‐4 group (n = 5)
	Ipsilateral	Contralateral	Ipsilateral	Contralateral
Striatum
DA	ND	5944 ± 313	ND	6769 ± 716
5‐HT	349 ± 68	472 ± 91	302 ± 54	434 ± 78
Cortex
NE	247 ± 26	257 ± 20	54 ± 15*	39 ± 10**
5‐HT	133 ± 26	132 ± 20	126 ± 18	168 ± 24

Each value, expressed in ng/mg of tissue, represents the mean ± SEM of 5–6 rats/group in unilaterally 6‐hydroxydopamine (6‐OHDA)‐lesioned rats. Brain tissues were collected 2 h after the end of microdialysis experiments that were performed 3–4 weeks after the unilateral injection of 6‐OHDA in the median forebrain bundle. One week before the microdialysis experiments, 6‐OHDA‐lesioned rats received 50 mg/kg DSP‐4 or its vehicle.

*P < 0.05 and **P < 0.01 versus the corresponding side of the vehicle group (Student's t‐test).

ND, not detectable.