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. 2014 Sep 2;20(11):982–990. doi: 10.1111/cns.12313

Figure 7.

Figure 7

PKC inhibition reverses the upregulation of dendritic spines at prelimbic cortical pyramidal neurons. (A) illustrates the dendritic spines from DMSO (top panel), kainate plus DMSO (middle), and the mix of CHE, kainate, and DMSO (bottom). (B) shows cumulative changes in spine number versus spine size in DMSO (blue symbols), kainate plus DMSO (red symbols), and the mix of CHE, kainate, and DMSO (green symbols). (C) shows the values of spine width in DMSO control (blue bar, n = 1520 spines), kainite‐induced anxiety mice (red, n = 972), and the mixing of CHE, kainate, and DMSO (green; n = 1211; asterisk, P < 0.05). (D) shows spine density (spines per micrometer) in DMSO control (blue bar, n = 10 neurons), kainite‐induced anxiety mice (red, n = 8), and the mix of CHE, kainate, and DMSO (green; n = 10; asterisk, P < 0.05).