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Schematic representation of 18F‐MPPF antagonist binding (Antago) indiscriminately labeling 5‐HT 1A receptors in a G‐coupled receptor state (functional and linked to the second messengers) and in uncoupled state (nonfunctional state). The agonist, 18F‐F15599 (Ago), binds specifically the G‐coupled receptor state (functional receptors) 19. Note that PET radioligands, at tracer dose, occupy only a small fraction of the available receptors.
