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. 2014 Jan 7;20(3):244–252. doi: 10.1111/cns.12203

Figure 5.

Figure 5

Sunitinib reduces the expression of nNOS increased by MPP + in SH‐SY5Y cells. (A) SH‐SY‐5Y cells were pretreated with sunitinib or DMSO (0.05%, vehicle control) at the indicated concentrations for 2 h and then treated with 1 mM MPP + for 24 h. The total proteins were extracted for Western blot analysis with specific nNOS and β‐actin antibodies. (B) Statistic analysis of nNOS expression in each treatment group. Data were expressed as the ratio of OD values to the corresponding controls. Data, expressed as percentage of control, were the mean ± SEM of three separate experiments; **P < 0.01 versus MPP + group (anova and Dunnett's test). nNOS, neuronal nitric oxide synthase.