Table 1.

Binding affinity values of agonists and antagonists acting on 5‐HT _1A or 5‐HT ₇ receptors

Compound	5‐HT1A receptor			5‐HT7 receptor
	Binding affinity	System	Reference	Binding affinity	System	Reference
8‐OH‐DPAT	Ki = 1.78 nM	Rat hippocampal membranes	52	Ki = 52 nM	Rat cloned receptor	53
WAY‐100635	IC50 = 1.35 nM	Rat hippocampal membranes	54	Ki > 10000 nM	Human cloned receptor	59
WAY‐100135	IC50 = 34 nM	Rat hippocampal membranes	55	Not available
NAN‐190	pKi = 9.2	Rat hippocampal membranes	126	Ki > 1000 nM	Rat cloned receptor	60
NAD‐299	Ki = 0.59 nM	Rat hippocampal membranes	58	Ki > 1000 nM	Rat cloned receptor	58
5‐CT	Ki = 0.53 nM	Human cloned receptor	127	IC50 = 0.83 nM	Rat cloned receptor	31
AS‐19	Ki = 89.7 nM	Human cloned receptor	66	Ki = 0.6 nM	Human cloned receptor	66
E‐55888	Ki = 700 nM	Human cloned receptor	66	Ki = 2.5 nM	Human cloned receptor	66
LP‐211	Ki = 15 nM	Human cloned receptor	67	Ki = 379 nM	Human cloned receptor	67
SB‐269970	pKi < 5	Human cloned receptor	128	pKi = 8.9	Human cloned receptor	128
SB‐258719	pKi < 5.1	Human cloned receptor	129	pKi = 7.5	Human cloned receptor	129
SB‐656104	pKi = 6.25	Human cloned receptor	130	pKi = 8.70	Human cloned receptor	130