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. 2015 Oct 28;21(12):953–961. doi: 10.1111/cns.12472

Figure 2.

Figure 2

B7C effectively inhibits Aβ1‐40 fibrils formation and disaggregates preformed Aβ1‐40 fibrils in a dose‐dependent manner. (A) HFIP‐reconstituted Aβ monomers (20 μM) were incubated at 37°C for 6 days with or without B7C (0.1–10 μM), tacrine (3–10 μM), or curcumin (1–3 μM). The extent of Aβ aggregation was evaluated using ThT fluorescence assay. *P < 0.05, **P < 0.01, compared to Aβ group. (B) The preformed Aβ fibrils were allowed for 3 days and then incubated at 37°C for another 3 days with compounds described in (A). *P < 0.05, **P < 0.01, compared to Aβ group.