Figure 3.
B7C markedly blocks Aβ1‐40‐induced neuronal death in SH‐SY5Y cells. (A) Aβ monomers (20 μM) were incubated at 37°C for 6 days with or without B7C (0.1–10 μM), tacrine (3–10 μM), or curcumin (1–3 μM) and then added into SH‐SY5Y cells. (B) The preformed Aβ fibrils were allowed for 3 days, then incubated at 37°C for another 3 days with compounds described in (A), and finally added into cells. Forty‐eight h after treatment, MTT assay was used to measure cell viability. **P < 0.01, compared to control group. ## P < 0.01, compared to Aβ group.