Table 1.
B7C reverses the dysfunction of ChAT and AChE activities induced by icv Aβ1–40 in rats
| Aβ1‐40 | ||||||
|---|---|---|---|---|---|---|
| B7C (mg/kg) | Tacrine (mg/kg) | |||||
| Vehicle | 0.1 | 0.2 | 1 | 2 | ||
| ChAT (% of control) | ||||||
| Cortex | 100 ± 8.1 | 78.9 ± 9.0# | 97.0 ± 7.2** | 92.0 ± 8.2* | 84.4 ± 4.3 | 88.2 ± 7.9 |
| Hippocampus | 100 ± 8.9 | 80.1 ± 10.5## | 96.9 ± 6.6* | 97.5 ± 13.2* | 90.5 ± 4.2* | 90.3 ± 4.1* |
| AChE (% of control) | ||||||
| Cortex | 100 ± 13.6 | 122.1 ± 6.9# | 117.0 ± 15.5 | 94.0 ± 6.6** | 103.2 ± 4.4* | 100. ± 4.7* |
| Hippocampus | 100 ± 8.0 | 104.1 ± 10.1 | 101.6 ± 8.0 | 102.1 ± 28.3 | 101.5 ± 8.5 | 100.7 ± 9.6 |
Rats were killed 2 h after the fifth performance of water maze. Saline (Vehicle), B7C or tacrine was administered once per day for 12 consecutive days. Data are expressed as means ± SEM (n = 7). # P < 0.05 and ## P < 0.01 vs. vehicle group; *P < 0.05 and **P < 0.01 vs. Aβ1–40‐treated group.