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. 2015 Sep 19;21(11):877–886. doi: 10.1111/cns.12447

Figure 5.

Figure 5

Endothelial progenitor cell (EPC) treatment promotes the activation of endothelial nitric oxide synthase (eNOS) and expression of brain‐derived neurotrophic factor (BDNF) on day 7 in the ischemic brain; however, these effects are not maintained after pretreatment with Nω‐nitro‐l‐arginine methyl ester (L‐NAME). Western blot analyses of the activation of eNOS (A) and the expression of BDNF and VEGF (B) in the ischemic brains of mice in various groups (n = 3/group). (C) Immunofluorescence staining revealed that only a few BDNF‐positive cells (red) were colabeled with GFAP (green) and that most of the BDNF‐positive cells (red) were colabeled with NeuN (green) in the peri‐infarct region of the mice treated with EPCs. Scale bar = 30 μm, *P < 0.05, **P < 0.01.