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Sildenafil protected neurons from injury via a cGMP‐dependent Nogo‐R pathway. The increase in surviving neurons (A, C) and the decrease in Nogo‐R expression (B, D) induced by sildenafil were significantly reversed by ODQ, IP‐20, or DT‐3. Scale bar = 50 μm. ### P < 0.001 compared with the sham‐operated group. **P < 0.01, ***P < 0.001 compared with the middle cerebral artery occlusion (MCAO) group. $ P < 0.05, $$$P < 0.001 compared with the MCAO + sildenafil group.
