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Sildenafil increased neuron survival by downregulation of the Nogo‐R pathway (A). Ischemia often causes low levels of synaptophysin (A) and high levels of uncoupling PSD‐95 (A) and nNOS (B), which could be blocked by sildenafil. ### P < 0.001 compared with the sham‐operated group, ***P < 0.001 compared with the middle cerebral artery occlusion (MCAO) group. Sildenafil could prevent synapse structure degeneration and demyelination in acute stroke (C). Scale bar = 500 nm.
