Images in an 82-year-old man with biopsy-proven prostate cancer arising
in both the transition zone (arrows) and peripheral zone (arrowheads).
A, Axial T2-weighted turbo spin-echo MRI shows
lenticular right paramidline transition zone tumor and right peripheral
zone tumor at 7 to 8 o’clock. Both have low signal intensity.
B, Apparent diffusion coefficient (ADC) map shows
that both tumors have reduced ADC. C, MRI obtained with
b value of 2000 sec/mm2 shows tumors
with high signal intensity. D, Early dynamic MRI
obtained with gadolinium-based contrast material shows enhancement of
both lesions. E, Axial Vascular, Extracellular, and
Restricted Diffusion for Cytometry in Tumors (VERDICT) map of
intracellular volume fraction shows tumors with increased intracellular
volume fraction. F, VERDICT map of extracellular
extravascular volume fraction shows reduction in degree of extracellular
extravascular space. G, VERDICT map of vascular volume
fraction shows tumors with equivocal-to-low vascular volume fraction
values. Methods for determining extracellular extravascular volume
fraction and vascular volume fraction, along with the results, are
provided in Appendix
E1 (online).