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. 2019 Apr 23;8(1):1603048. doi: 10.1080/20013078.2019.1603048

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — In vitro assays for EVs neurotrophic activity assessment of ODG purified EVs. (a) Outgrowth measurements of leech neurons exposed for 14 days to complete medium (Control, n = 38) or to vesicles from ODG EV-rich fractions (n = 37). Each open circle represents the percentage of neurite outgrowth from individual neurons. Bars indicate the average values for each series of measurements. A significant difference was observed between the two conditions with a p-value of 0.0029. (b) and (c) pictures display an example of neurite outrgrowth recorded for the same neurone at 6 and 20 days of culture with L15 medium alone (Control) or containing 10⁶ EVs/well (ODG EV-rich fractions). Scale bars correspond to 20 µm.